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Responder and non-responder proteomic and phosphoproteomic profiles to ATRA/Valproic acid before treatment

ABSTRACT: Proteomic and phosphoproteomic raw files from responder and non-responder acute myeloid leukemia patient samples before initiation of ATRA/valproic acid treatment

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Maria Hernandez-Valladares

LAB HEAD: Maria Hernandez-Valladares

PROVIDER: PXD024110 | Pride | 2021-09-10

REPOSITORIES: Pride

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Publications

Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid.

Hernandez-Valladares Maria M Wangen Rebecca R Aasebø Elise E Reikvam Håkon H Berven Frode S FS Selheim Frode F Bruserud Øystein Ø

Cancers 20210429 9

All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and improve normal peripheral blood cell counts. In this context, we used a proteomic/phosphoproteomic strategy to investigate the in vivo effects of ATRA/VP on human AML cells. Before starting the combined treatment, AML responders showed increased levels of several proteins, espe ...[more]

PMID: 33946813

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