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Peptidomics of pancreas in wild type and neuronatin deficien mice

ABSTRACT: Pancreata of wild type and a neuronatin deficient mouse strain were homogenised and the peptidome characterised. Particular attention was paid to the processing of insulin, to assess if neuronatin deficiency causes changes in the processing efficiency of insulin and other bioactive peptides produced in the pancreas

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreas

SUBMITTER: Richard Kay

LAB HEAD: Dr Anthony Coll

PROVIDER: PXD024161 | Pride | 2021-11-03

REPOSITORIES: Pride

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Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.

Cimino Irene I Rimmington Debra D Tung Y C Loraine YCL Lawler Katherine K Larraufie Pierre P Kay Richard G RG Virtue Samuel S Lam Brian Y H BYH Fagnocchi Luca L Ma Marcella K L MKL Saudek Vladimir V Zvetkova Ilona I Vidal-Puig Antonio A Yeo Giles S H GSH Farooqi I Sadaf IS Pospisilik J Andrew JA Gribble Fiona M FM Reimann Frank F O'Rahilly Stephen S Coll Anthony P AP

Scientific reports 20210902 1

Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat<sup>+/-p</sup> mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient ...[more]

PMID: 34475432

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