Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte
DISEASE(S): Disease Free
SUBMITTER: Sun Young Lee
LAB HEAD: Jin Gyeong Son
PROVIDER: PXD024206 | Pride | 2021-09-10
REPOSITORIES: Pride
Lee Sun Young SY Kim In Young IY Heo Min Beom MB Moon Jeong Hee JH Son Jin Gyeong JG Lee Tae Geol TG
Biomolecules 20210302 3
Silica nanoparticles (SiO<sub>2</sub> NPs) are commonly used in medical and pharmaceutical fields. Research into the cytotoxicity and overall proteomic changes occurring during initial exposure to SiO<sub>2</sub> NPs is limited. We investigated the mechanism of toxicity in human liver cells according to exposure time [0, 4, 10, and 16 h (h)] to SiO<sub>2</sub> NPs through proteomic analysis using mass spectrometry. SiO<sub>2</sub> NP-induced cytotoxicity through various pathways in HepG2 cells. ...[more]