Proteomics

Dataset Information

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Ferlins and TgDOC2 in Toxoplasma microneme, rhoptry and dense granule secretion


ABSTRACT: Stable Isotope Labeling with Amino acids in Cell culture (SILAC) proteomics on the proteinsreleased in a set of T. gondii secretion mutants.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Toxoplasma Gondii Ctco5

SUBMITTER: Eranthie Weerapana  

LAB HEAD: Eranthie Weerapana

PROVIDER: PXD024210 | Pride | 2021-09-10

REPOSITORIES: Pride

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Publications

Ferlins and TgDOC2 in <i>Toxoplasma</i> Microneme, Rhoptry and Dense Granule Secretion.

Tagoe Daniel N A DNA   Drozda Allison A AA   Falco Julia A JA   Bechtel Tyler J TJ   Weerapana Eranthie E   Gubbels Marc-Jan MJ  

Life (Basel, Switzerland) 20210309 3


The host cell invasion process of apicomplexan parasites like <i>Toxoplasma gondii</i> is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family. This class of C2 domains is derived from an ancestral calcium (Ca<sup>2+</sup>) binding archetype, although this feature is optional in extant C2 domains. DOC2 domains provide combinatorial power to the C2 domain, which is further enhanced in fer  ...[more]

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