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MiR-146 modulation in ALS astrocytes

ABSTRACT: Regarding astrocytes and microglia, we are looking for pathways related with inflammatory activation, phagocytosis and vesicular/exosome trafficking. Regarding motor neurons, we are searching for pathways related with mitochondrial dynamics, Endoplasmic Reticulum stress, cell death, axonal transport, synaptic vesicles transport and oxidative stress. The general aim is to identify putative hits in ALS that relates with miR-146a expression.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spinal Cord Motor Neuron, Astrocyte Of The Cerebral Cortex, Cell Culture, Microglial Cell

DISEASE(S): Amyotrophic Lateral Sclerosis

SUBMITTER: Frank Stein

LAB HEAD: Dora Brites

PROVIDER: PXD024294 | Pride | 2021-04-06

REPOSITORIES: Pride

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