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Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals new features of arthritogenic alphaviruses

ABSTRACT: Characterize the glycosylation sites in E1 and E2, which are transmembrane proteins that are organized in heterodimers.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human) Mayaro Virus (strain Brazil)

SUBMITTER: Adriana Franco Paes Leme

LAB HEAD: Adriana Franco Paes Leme

PROVIDER: PXD024432 | Pride | 2021-05-28

REPOSITORIES: Pride

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Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses.

Ribeiro-Filho Helder V HV Coimbra Lais D LD Cassago Alexandre A Rocha Rebeca P F RPF Guerra João Victor da Silva JVDS de Felicio Rafael R Carnieli Carolina Moretto CM Leme Luiza L Padilha Antonio Cláudio AC Paes Leme Adriana F AF Trivella Daniela B B DBB Portugal Rodrigo Villares RV Lopes-de-Oliveira Paulo Sérgio PS Marques Rafael Elias RE

Nature communications 20210524 1

Mayaro virus (MAYV) is an emerging arbovirus of the Americas that may cause a debilitating arthritogenic disease. The biology of MAYV is not fully understood and largely inferred from related arthritogenic alphaviruses. Here, we present the structure of MAYV at 4.4 Å resolution, obtained from a preparation of mature, infective virions. MAYV presents typical alphavirus features and organization. Interactions between viral proteins that lead to particle formation are described together with a hydr ...[more]

PMID: 34031424

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