Mitochondria shed large SPOTs during infection-induced import stress to remodel their outer membrane
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF
ORGANISM(S): Homo Sapiens (human) Toxoplasma Gondii
SUBMITTER: 
Ilian Atanassov
LAB HEAD: Lena Pernas
PROVIDER: PXD024491 | Pride | 2022-08-04
REPOSITORIES: Pride
Publications
Mitochondria shed their outer membrane in response to infection-induced stress.
Li Xianhe X Straub Julian J Medeiros Tânia Catarina TC Mehra Chahat C den Brave Fabian F Peker Esra E Atanassov Ilian I Stillger Katharina K Michaelis Jonas Benjamin JB Burbridge Emma E Adrain Colin C Münch Christian C Riemer Jan J Becker Thomas T Pernas Lena F LF
Science (New York, N.Y.) 20220114 6577
The outer mitochondrial membrane (OMM) is essential for cellular homeostasis. Yet little is known of the mechanisms that remodel it during natural stresses. We found that large “SPOTs” (structures positive for OMM) emerge during <i>Toxoplasma gondii</i> infection in mammalian cells. SPOTs mediated the depletion of the OMM proteins mitofusin 1 and 2, which restrict parasite growth. The formation of SPOTs depended on the parasite effector TgMAF1 and the host mitochondrial import receptor TOM70, wh ...[more]
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