Dataset Information


Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

ABSTRACT: COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared first in Wuhan, Hubei, China, has emerged as a global health concern claiming millions of lives worldwide. Syrian golden hamster (Mesocricetus auratus) has emerged as a suitable model as when infected by SARS-CoV-2, manifests lung pathology resembling human COVID-19 patients. In this study, we employed a quantitative approach to study the proteomic changes in the SARS-CoV-2-infected lung tissue. The samples were analyzed using Orbitrap Fusion Tribrid mass spectrometer in triplicates and the data acquired was searched against Mesocricetus auratus protein database which resulted in the identification of nearly 2,000 non-redundant proteins. The outcome of this study will facilitate in discovery of potential candidate biomarkers for predicting disease course and warrants their further validation in human patient samples.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 Mesocricetus Auratus (golden Hamster)


SUBMITTER: Shantibhusan Senapati  

LAB HEAD: Dr. Shantibhusan Senapati

PROVIDER: PXD024547 | Pride | 2021-11-03


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Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity.

Suresh Voddu V   Mohanty Varshasnata V   Avula Kiran K   Ghosh Arup A   Singh Bharati B   Reddy Rajendra Kumar RK   Parida Deepti D   Suryawanshi Amol Ratnakar AR   Raghav Sunil Kumar SK   Chattopadhyay Soma S   Prasad Punit P   Swain Rajeeb Kumar RK   Dash Rupesh R   Parida Ajay A   Syed Gulam Hussain GH   Senapati Shantibhusan S  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20210701 7

Syrian golden hamsters (Mesocricetus auratus) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests lung pathology. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in a self-limiting and non-lethal hamster model and evaluate the differential expression of lung proteins during acute infection and convalescence. The findings of this study confirm the infectivity of this isolate in vivo. Analysis of clinical parameters and tissue  ...[more]

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