Identification of Mfn2 interacting proteins in homeostatic endothelial cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Laura Herring
LAB HEAD: Jalees Rehman
PROVIDER: PXD024620 | Pride | 2021-03-11
REPOSITORIES: Pride
Publications
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling.
Kim Young-Mee YM Krantz Sarah S Jambusaria Ankit A Toth Peter T PT Moon Hyung-Geun HG Gunarathna Isuru I Park Gye Young GY Rehman Jalees J
Nature communications 20210512 1
Endothelial barrier integrity is ensured by the stability of the adherens junction (AJ) complexes comprised of vascular endothelial (VE)-cadherin as well as accessory proteins such as β-catenin and p120-catenin. Disruption of the endothelial barrier due to disassembly of AJs results in tissue edema and the influx of inflammatory cells. Using three-dimensional structured illumination microscopy, we observe that the mitochondrial protein Mitofusin-2 (Mfn2) co-localizes at the plasma membrane with ...[more]
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