Control and Ikbkap-knockout MEFs LC-MSMS

ABSTRACT: Mouse Ikbkap gene encodes IKAP/Elp1- one of the core subunits of Elongator- and has been implicated in translational regulation. However, a role for IKAP in genome maintenance remains unclear. In this study, we analyze proteins from control and Ikbkap depletion mouse embryonic fibroblasts (MEF) using MS. Using MS-based proteomics, we show that several proteins involved in cancer and DNA damage response were found to be differentially expressed upon Ikbkap depletion.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryonic Fibroblast, Fibroblast

DISEASE(S): Riley-day Syndrome

SUBMITTER: FU-JUNG LIN  

LAB HEAD: Fu-Jung Lin

PROVIDER: PXD024628 | Pride | 2022-02-17

REPOSITORIES: Pride