Analysis of mouse liver secretome and proteome during nonalcoholic steatohepatitis
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ABSTRACT: Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. Using proteomic approaches, we interrogated hepatocyte protein secretion in two models of murine NASH to reveal striking hepatokine remodelling that is associated with insulin resistance and maladaptive lipid metabolism.
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
DISEASE(S): Non-alcoholic Steatohepatitis
SUBMITTER: Benjamin Parker
LAB HEAD: Benjamin Parker
PROVIDER: PXD024673 | Pride | 2022-02-27
REPOSITORIES: Pride
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