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Identification of kinase activity in ischemic heart disease

ABSTRACT: We performed discovery proteomics and phosphoproteomics analysis of human heart tissue to identify possibly hyperactive pathways in ischemic heart disease.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

DISEASE(S): Myocardial Ischemia

SUBMITTER: Thomas Michna

LAB HEAD: Stefan Tenzer

PROVIDER: PXD024727 | Pride | 2023-03-11

REPOSITORIES: Pride

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Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1-driven fibrotic remodeling in ischemic heart failure.

Garlapati Venkata V Molitor Michael M Michna Thomas T Harms Gregory S GS Finger Stefanie S Jung Rebecca R Lagrange Jeremy J Efentakis Panagiotis P Wild Johannes J Knorr Maike M Karbach Susanne S Wild Sabine S Vujacic-Mirski Ksenija K Münzel Thomas T Daiber Andreas A Brandt Moritz M Gori Tommaso T Milting Hendrik H Tenzer Stefan S Ruf Wolfram W Wenzel Philip P

The Journal of clinical investigation 20230215 4

Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify a profibrotic coagulation signaling pathway that can be targeted for improved cardiac function following MI with persistent ischemia. Quantitative phosphoproteomics of cardiac tissue revealed an upregulated mitogen-activated protein kinase (MAPK) pathway in human IHF. ...[more]

PMID: 36548062

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