Ontology highlight
ABSTRACT:
INSTRUMENT(S): Xevo G2-S QTof
ORGANISM(S): Homo Sapiens (human) Human Alphaherpesvirus 1
TISSUE(S): Cell Culture
SUBMITTER: Ilaria Frasson
LAB HEAD: Prof. Sara N. Richter
PROVIDER: PXD024743 | Pride | 2021-09-10
REPOSITORIES: Pride
Frasson Ilaria I Soldà Paola P Nadai Matteo M Lago Sara S Richter Sara N SN
Communications biology 20210430 1
G-quadruplexes (G4s) are four-stranded nucleic acid structures abundant at gene promoters. They can adopt several distinctive conformations. G4s have been shown to form in the herpes simplex virus-1 (HSV-1) genome during its viral cycle. Here by cross-linking/pull-down assay we identified ICP4, the major HSV-1 transcription factor, as the protein that most efficiently interacts with viral G4s during infection. ICP4 specific and direct binding and unfolding of parallel G4s, including those presen ...[more]