LC-MSMS of Extracellular Vesicles Derived from Human Mesenchymal Stem Cells after Priming
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Multipotent Stem Cell, Bone Marrow
DISEASE(S): Disease Free
SUBMITTER: 
Lisa Pierce
LAB HEAD: Lisa M. Pierce
PROVIDER: PXD024790 | Pride | 2021-06-16
REPOSITORIES: Pride
Publications
Priming With Toll-Like Receptor 3 Agonist Poly(I:C) Enhances Content of Innate Immune Defense Proteins but Not MicroRNAs in Human Mesenchymal Stem Cell-Derived Extracellular Vesicles.
Pierce Lisa M LM Kurata Wendy E WE
Frontiers in cell and developmental biology 20210524
Mesenchymal stem cells (MSCs) help fight infection by promoting direct bacterial killing or indirectly by modulating the acute phase response, thereby decreasing tissue injury. Recent evidence suggests that extracellular vesicles (EVs) released from MSCs retain antimicrobial characteristics that may be enhanced by pretreatment of parent MSCs with the toll-like receptor 3 (TLR3) agonist poly(I:C). Our aim was to determine whether poly(I:C) priming can modify EV content of miRNAs and/or proteins t ...[more]
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