Aquaporin-4 mRNA binding proteins
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap XL ETD
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spinal Cord
SUBMITTER: 
Francesco Pisani
LAB HEAD: Francesco Pisani
PROVIDER: PXD024792 | Pride | 2021-05-27
REPOSITORIES: Pride
Publications
Regulation of aquaporin-4 expression in the central nervous system investigated using M23-AQP4 null mouse.
Pisani Francesco F Simone Laura L Mola Maria Grazia MG De Bellis Manuela M Frigeri Antonio A Nicchia Grazia Paola GP Svelto Maria M
Glia 20210526 9
In astrocytes, unknown mechanisms regulate the expression of M1 and M23 isoforms of water channel aquaporin-4 (M1-AQP4 and M23-AQP4). The ratio between these two isoforms controls the AQP4 assembly state in the plasma membrane known as orthogonal arrays of particles (OAPs). To give new insights into these mechanisms, here, we explore the regulation of AQP4 expression in the spinal cord of a CRISPR/Cas9 M23-null mouse model (M23-null). In the M23-null spinal cord OAP assembly, the perivascular lo ...[more]
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