Proteomics

Dataset Information

0

The proteome and phosphoproteome of acute stress in the mouse hippocampus


ABSTRACT: The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, little is known about the nature and dynamics of the underlying molecular cascades. We used a brief forced swim exposure to trigger a strong stress response in mice, which transiently increases anxiety, but does not lead to lasting maladaptive behavioral changes. Using multiomic profiling we characterize the stress-induced molecular events in the hippocampus over time, across molecular scales, and down to the level of cell types and single cells. Our results unveil the complexity and specificity of the healthy stress response, with widespread changes in protein phosphorylation and gene transcription, but tightly regulated protein translation. All observed molecular events resolve efficiently within 4 hours after initiation of stress.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hippocampal Formation, Hippocampus

DISEASE(S): Acute Stress Disorder

SUBMITTER: Lukas von Ziegler  

LAB HEAD: Johannes Bohacek

PROVIDER: PXD024829 | Pride | 2022-02-09

REPOSITORIES: Pride

Similar Datasets

2022-02-09 | PXD029903 | Pride
2011-09-30 | E-GEOD-28485 | biostudies-arrayexpress
2007-10-01 | E-GEOD-8014 | biostudies-arrayexpress
2011-09-30 | E-GEOD-28486 | biostudies-arrayexpress
2022-11-11 | PXD037724 | Pride
2024-04-11 | PXD043012 | Pride
2019-03-06 | PXD011551 | Pride
2022-11-11 | PXD026426 | Pride
2008-12-10 | E-GEOD-13903 | biostudies-arrayexpress
2008-11-03 | E-GEOD-13293 | biostudies-arrayexpress