Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer’s Disease

ABSTRACT: The linear sequence of amino acids in a protein folds into a 3D structure to execute protein activity and function, but it is still challenging to profile the 3D structure at the proteome scale. Here, we present a method of native protein tandem mass tag (TMT) profiling of Lys accessibility and its application to investigate structural alterations in human brain specimens of Alzheimer’s disease (AD).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Kaiwen Yu  

LAB HEAD: Junmin Peng

PROVIDER: PXD024914 | Pride | 2021-03-23

REPOSITORIES: Pride