ANALYSIS OF NETWORKS IN THE DORSOLATERAL PREFRONTAL CORTEX IN CHRONIC SCHIZOPHRENIA: RELEVANCE OF ALTERED IMMUNE RESPONSE

ABSTRACT: The dorsolateral prefrontal cortex (DLPFC) is the association area in the anterior part of the frontal lobe and has a crucial role in cognitive functioning and negative symptoms in SZschizophrenia. However, limited information of altered protein networks is available in this region in schizophrenia. We performed a proteomic analysis using single-shot liquid chromatography-tandem mass spectrometry of grey matter of postmortem DLPFC in chronic schizophrenia subjects (n=20) and healthy individuals (n=20) followed by bioinformatic analysis to identify altered protein networks in SZ.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Ricard Rodriguez-Mias  

LAB HEAD: Judit Villen

PROVIDER: PXD024939 | Pride | 2023-05-10

REPOSITORIES: Pride