Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Ascites
SUBMITTER: Stacy Malaker
LAB HEAD: Stacy Malaker
PROVIDER: PXD024995 | Pride | 2022-06-29
REPOSITORIES: Pride
Malaker Stacy A SA Riley Nicholas M NM Shon D Judy DJ Pedram Kayvon K Krishnan Venkatesh V Dorigo Oliver O Bertozzi Carolyn R CR
Nature communications 20220620 1
Mucin domains are densely O-glycosylated modular protein domains found in various extracellular and transmembrane proteins. Mucin-domain glycoproteins play important roles in many human diseases, such as cancer and cystic fibrosis, but the scope of the mucinome remains poorly defined. Recently, we characterized a bacterial O-glycoprotease, StcE, and demonstrated that an inactive point mutant retains binding selectivity for mucin-domain glycoproteins. In this work, we leverage inactive StcE to se ...[more]