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ITRAQ analysis of Metformin treated AGS cells

ABSTRACT: AGS cells were treated with metformin then performed iTRAQ proteomics techniques.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stomach, Epithelium Of Stomach

DISEASE(S): Stomach Cancer

SUBMITTER: Wang Weihsuan

LAB HEAD: Hsueh-Fen Juan

PROVIDER: PXD024996 | Pride | 2021-09-10

REPOSITORIES: Pride

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Proteomic Analysis Reveals That Metformin Suppresses PSMD2, STIP1, and CAP1 for Preventing Gastric Cancer AGS Cell Proliferation and Migration.

Wang Wei-Hsuan WH Chen Szu-Kai SK Huang Hsuan-Cheng HC Juan Hsueh-Fen HF

ACS omega 20210526 22

Metformin is one of the most widely used anti-diabetic drugs in type-II diabetes treatment. The mechanism of decreasing blood glucose is believed to suppress hepatic gluconeogenesis by increasing muscular glucose uptake and insulin sensitivity. Recent studies suggest that metformin may reduce cancer risk; however, its anticancer mechanism in gastric cancers remains unclear. Here, we aim to evaluate the anticancer effects of metformin on human gastric adenocarcinoma (AGS) cells. Our results showe ...[more]

PMID: 34124444

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