Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: Stephane Claverol
LAB HEAD: Marc Bonneu
PROVIDER: PXD024998 | Pride | 2022-02-17
REPOSITORIES: Pride
Laferrière Florent F Claverol Stéphane S Bezard Erwan E De Giorgi Francesca F Ichas François F
NPJ Parkinson's disease 20220113 1
Aggregated alpha-synuclein (α-syn) is a principal constituent of Lewy bodies (LBs) and glial cytoplasmic inclusions (GCIs) observed respectively inside neurons in Parkinson's disease (PD) and oligodendrocytes in multiple system atrophy (MSA). Yet, the cellular origin, the pathophysiological role, and the mechanism of formation of these inclusions bodies (IBs) remain to be elucidated. It has recently been proposed that α-syn IBs eventually cause the demise of the host cell by virtue of the cumula ...[more]