Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Rattus Norvegicus (rat) Homo Sapiens (human)
SUBMITTER: Alex Zelter
LAB HEAD: Michael MacCoss
PROVIDER: PXD025019 | Pride | 2022-02-24
REPOSITORIES: Pride
Riffle Michael M Hoopmann Michael R MR Jaschob Daniel D Zhong Guo G Moritz Robert L RL MacCoss Michael J MJ Davis Trisha N TN Isoherranen Nina N Zelter Alex A
Analytical chemistry 20220220 8
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life-threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass spectrometry-based proteomics approaches incapable of adduct identification. Here, we present Magnum, an open-mass search algorithm optimized for adduct identification, and Limelight, a web-based data processing package ...[more]