Dataset Information

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

ABSTRACT: Using omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. Targeted analysis of the alveolar and microvascular niche revealed a dominant role for monocyte-derived macrophages and endothelial cells regarding early anti-viral genes as well as pro-inflammatory and T cell recruiting chemokine expression. Recruitment of cytotoxic effector T cells coincided with viral clearance. This combined response was favorable for a moderate and self-limited disease course.

INSTRUMENT(S): TripleTOF 6600, Q Exactive Plus

ORGANISM(S): Mesocricetus Auratus (golden Hamster)

TISSUE(S): Lung, Blood Serum

DISEASE(S): Covid-19

SUBMITTER: Michael Mülleder

LAB HEAD: Michael Muelleder

PROVIDER: PXD025164 | Pride | 2021-06-17

REPOSITORIES: Pride

ACCESS DATA

Publications

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.

Nouailles Geraldine G Wyler Emanuel E Pennitz Peter P Postmus Dylan D Vladimirova Daria D Kazmierski Julia J Pott Fabian F Dietert Kristina K Muelleder Michael M Farztdinov Vadim V Obermayer Benedikt B Wienhold Sandra-Maria SM Andreotti Sandro S Hoefler Thomas T Sawitzki Birgit B Drosten Christian C Sander Leif E LE Suttorp Norbert N Ralser Markus M Beule Dieter D Gruber Achim D AD Goffinet Christine C Landthaler Markus M Trimpert Jakob J Witzenrath Martin M

Nature communications 20210811 1

In COVID-19, immune responses are key in determining disease severity. However, cellular mechanisms at the onset of inflammatory lung injury in SARS-CoV-2 infection, particularly involving endothelial cells, remain ill-defined. Using Syrian hamsters as a model for moderate COVID-19, we conduct a detailed longitudinal analysis of systemic and pulmonary cellular responses, and corroborate it with datasets from COVID-19 patients. Monocyte-derived macrophages in lungs exert the earliest and stronges ...[more]

PMID: 34381043

Dataset Information

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

Publications

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Similar Datasets

Organism-wide secretome mapping of tissue crosstalk in exercise
2023-07-21 | PXD034535 | Pride

Genome-wide transcriptomic profiles of the lungs of SARS-CoV-2 infected hamsters treated with the CYP19A1 inhibitor letrozole.
2023-06-30 | E-MTAB-13100 | biostudies-arrayexpress

Single cell RNA-seq of human CD8+ T cells binding the IAV HLA-A24/PB1 498-505 tetramer
2021-04-08 | E-MTAB-10109 | biostudies-arrayexpress

Simple and efficient micro-SPE tip-based sample preparation workflow to enable sensitive proteomic profiling of limited samples
2021-02-23 | PXD022313 | Pride

Preterm birth increases endogenous human milk peptide release compared to term birth
2016-07-07 | PXD001079 | Pride

RNA-seq data of four Lupinus angustifolius lines profiled for anthracnose resistance, based on leaves RNA isolates from inoculated and control (mock-inoculated) plants
2022-11-02 | E-MTAB-11164 | biostudies-arrayexpress

RNA-seq of Ruminococcus bromii L2-63 and Ruminococcus gnavus ATCC 29149 grown in mono- or co-culture with different carbon sources (glucose, soluble or resistant starch)
2019-07-31 | E-MTAB-7138 | biostudies-arrayexpress

IMP2/IGF2BP2 HITS-CLIP from E13.5 mouse brain
2016-06-06 | E-MTAB-3636 | biostudies-arrayexpress

Fast proteomics with dia-PASEF and analytical flow-rate chromatography
2023-07-03 | PXD040205 | Pride