Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

ABSTRACT: Using omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. Targeted analysis of the alveolar and microvascular niche revealed a dominant role for monocyte-derived macrophages and endothelial cells regarding early anti-viral genes as well as pro-inflammatory and T cell recruiting chemokine expression. Recruitment of cytotoxic effector T cells coincided with viral clearance. This combined response was favorable for a moderate and self-limited disease course.

INSTRUMENT(S):

ORGANISM(S): Mesocricetus Auratus (golden Hamster)

TISSUE(S): Lung, Blood Serum

DISEASE(S): Covid-19

SUBMITTER: Michael Mülleder  

LAB HEAD: Michael Muelleder

PROVIDER: PXD025164 | Pride | 2021-06-17

REPOSITORIES: Pride