Proteomics

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OPC Cell Culture with LPC 18:1 or LPC 18:1 (both + C13-His)

ABSTRACT: Rat OPCs were incubated in the presence of LPC 18:1 or LPC 18:0 and C13-His. Cultures controls included no treatment and a positive control for the differentiation of OPCs. LPC 18:1 was administered at 10 uM while C13-His was administered at 10 uM. Samples were process for mass spectrometry to identify the incorporation of C13-His in newly synthesized proteins.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Oligodendrocyte Precursor Cell, Cell Culture

SUBMITTER: Sanjoy Bhattacharya  

LAB HEAD: Sanjoy Bhattacharya

PROVIDER: PXD025177 | Pride | 2022-02-17

REPOSITORIES: Pride

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Publications

Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function.

Valdivia Anddre Osmar AO   Bhattacharya Sanjoy K SK  

eNeuro 20220126 1

Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our <i>in vitro</i> studies show LPC 18:1 protection against neuron-ectopic hyperdeimination and stimulation of oligodendrocyte maturation, while <i>in vivo  ...[more]

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