Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Kidney, Subcutaneous Adipose Tissue
DISEASE(S): Amyloidosis
SUBMITTER: 
Giulia Mazzini
LAB HEAD: Giovanni Palladini
PROVIDER: PXD025185 | Pride | 2022-08-12
REPOSITORIES: Pride
Publications
Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation.
Mazzini Giulia G Ricagno Stefano S Caminito Serena S Rognoni Paola P Milani Paolo P Nuvolone Mario M Basset Marco M Foli Andrea A Russo Rosaria R Merlini Giampaolo G Palladini Giovanni G Lavatelli Francesca F
The FEBS journal 20210915 2
Light-chain (AL) amyloidosis is characterized by deposition of immunoglobulin light chains (LC) as fibrils in target organs. Alongside the full-length protein, abundant LC fragments are always present in AL deposits. Herein, by combining gel-based and mass spectrometry analyses, we identified and compared the fragmentation sites of amyloid LCs from multiple organs of an AL λ amyloidosis patient (AL-55). The positions pinpointed here in kidney and subcutaneous fat, alongside those previously dete ...[more]
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