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Autologous Dendritic Cells Loaded with Allogenic Tumor Lysate for Surgically Resected Pancreatic Cancer Patients. Rationale and Clinical Results of a Phase II Study (REACtiVe Trial)

ABSTRACT: Determination of shared antigens in Pancreatic ductal adenocarcinoma (PDAC) tumor lysate and the allogeneic tumor drug product. The list of tumor antigenes was thereby dervied from preceeding RNA and literature research (e.g. [Cheevers et al 2009](https://europepmc.org/article/MED/19723653)).

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreas, Epithelium Of Pancreatic Duct

DISEASE(S): Pancreatic Ductal Adenocarcinoma

SUBMITTER: Christoph Stingl

LAB HEAD: Theo M. Luider

PROVIDER: PXD025210 | Pride | 2022-08-17

REPOSITORIES: Pride

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Dataset from a proteomics analysis of tumor antigens shared between an allogenic tumor cell lysate vaccine and pancreatic tumor tissue.

Stingl C C Lau S P SP van der Burg S H SH Aerts J G JG van Eijck C H J CHJ Luider T M TM

Data in brief 20220725

The data described was acquired as part of a clinical study with the aim to investigate the potential of tumor-reactive T-cell response as response to vaccination of pancreatic cancer patients with an allogenic tumor cell lysate vaccine (Lau et al., 2022). Proteomics analysis was carried out to identify tumor antigens that are shared between the allogeneic tumor cell lysate used for the vaccine and pancreatic ductal adenocarcinoma (PDAC) tissue samples. To this objective, cell lysates of the vac ...[more]

PMID: 35959468

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