27-plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer's Disease

ABSTRACT: Systematically optimized the protocol for the newly developed 16-plex TMT Reported a novel 27-plex method to enhance the multiplexity for large-scale proteomic profiling, by combining two sets of distinct isobaric tags (11-plex and 16-plex TMT) based on their disparate mass shifts on modified peptides.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Cerebral Cortex

DISEASE(S): Alzheimer's Disease

SUBMITTER: Zhen Wang  

LAB HEAD: Junmin Peng

PROVIDER: PXD025261 | Pride | 2021-04-09

REPOSITORIES: Pride