BioID-based proteomic analysis of CARP3-proximal proteins in Trypanosoma brucei bloodstream forms

ABSTRACT: How flagellar signaling regulates the host interaction of parasites remains a challenge due to poor conservation of signaling systems with those in cilia of higher organisms. The trypanosome-specific cAMP response protein 3 (CARP3) shows developmentally regulated localization at the flagellar tip membrane, where it is essential for parasite swarming and colonization of the tsetse fly insect vector. This project describes a proximity-dependent proteomics approach (BioID) that identified proteins in close vicinity of CARP3 in the bloodstream stage of Trypanosoma brucei.

INSTRUMENT(S):

ORGANISM(S): Trypanosoma Brucei

SUBMITTER: Dupuy Jean-William  

LAB HEAD: Michael Boshart

PROVIDER: PXD025357 | Pride | 2022-08-17

REPOSITORIES: Pride