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To the islands their own: Venomics of the enigmatic Andaman cobra (N. sagittifera) and the preclinical failure of Indian antivenoms in Andaman and Nicobar Islands

ABSTRACT: In this study, we unveil the venom composition, biochemistry, pharmacological activity, and potency of the Andaman cobra (N. sagittifera).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Naja Naja Naja Sagittifera

TISSUE(S): Venom

SUBMITTER: Kartik Sunagar

LAB HEAD: Dr. Kartik Sunagar

PROVIDER: PXD025362 | Pride | 2022-02-17

REPOSITORIES: Pride

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Venomics of the Enigmatic Andaman Cobra (Naja sagittifera) and the Preclinical Failure of Indian Antivenoms in Andaman and Nicobar Islands.

Attarde Saurabh S Khochare Suyog S Iyer Ashwin A Dam Paulomi P Martin Gerard G Sunagar Kartik K

Frontiers in pharmacology 20211025

The Andaman and Nicobar Islands are an abode to a diversity of flora and fauna, including the many endemic species of snakes, such as the elusive Andaman cobra (Naja sagittifera). However, the ecology and evolution of venomous snakes inhabiting these islands have remained entirely uninvestigated. This study aims to bridge this knowledge gap by investigating the evolutionary history of N. sagittifera and its venom proteomic, biochemical and toxicity profile. Phylogenetic reconstruct ...[more]

PMID: 34759827

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