Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human) Human Immunodeficiency Virus
SUBMITTER: Robyn Kaake
LAB HEAD: Nevan J. Krogan
PROVIDER: PXD025391 | Pride | 2021-11-03
REPOSITORIES: Pride
Kaake Robyn M RM Echeverria Ignacia I Kim Seung Joong SJ Von Dollen John J Chesarino Nicholas M NM Feng Yuqing Y Yu Clinton C Ta Hai H Chelico Linda L Huang Lan L Gross John J Sali Andrej A Krogan Nevan J NJ
Molecular & cellular proteomics : MCP 20210811
Structural analysis of host-pathogen protein complexes remains challenging, largely due to their structural heterogeneity. Here, we describe a pipeline for the structural characterization of these complexes using integrative structure modeling based on chemical cross-links and residue-protein contacts inferred from mutagenesis studies. We used this approach on the HIV-1 Vif protein bound to restriction factor APOBEC3G (A3G), the Cullin-5 E3 ring ligase (CRL5), and the cellular transcription fact ...[more]