Identification of CARP3-interacting proteins in Trypanosoma brucei bloodstream forms and procyclic forms

ABSTRACT: How flagellar signaling regulates the host interaction of parasites remains a challenge due to poor conservation of signaling systems with those in cilia of higher organisms. The trypanosome-specific cAMP response protein 3 (CARP3) shows developmentally regulated localization at the flagellar tip membrane, where it is essential for parasite swarming and colonization of the tsetse fly insect vector. This project describes identification of CARP3-YFP interacting proteins by GFP trap pull down followed by mass spectrometry in the bloodstream stage as well as in the procyclic stage of Trypanosoma brucei.

INSTRUMENT(S):

ORGANISM(S): Trypanosoma Brucei Brucei

SUBMITTER: Ignasi Forne  

LAB HEAD: Boshart, Michael

PROVIDER: PXD025398 | Pride | 2022-08-31

REPOSITORIES: Pride