Quantitative proteomics upon CARP3 knock down in Trypanosoma brucei bloodstream forms

ABSTRACT: How flagellar signaling regulates the host interaction of parasites remains a challenge due to poor conservation of signaling systems with those in cilia of higher organisms. The trypanosome-specific cAMP response protein 3 (CARP3) shows developmentally regulated localization at the flagellar tip membrane, where it is essential for parasite swarming and colonization of the tsetse fly insect vector. This project describes a label-free, quantitative proteomics approach that identifies proteins changing in abundance upon inducible CARP3 knock down in bloodstream stage Trypanosoma brucei.

INSTRUMENT(S):

ORGANISM(S): Trypanosoma Brucei Brucei

SUBMITTER: Ignasi Forne  

LAB HEAD: Boshart, Michael

PROVIDER: PXD025401 | Pride | 2022-08-31

REPOSITORIES: Pride