Proteomic analysis of membrane vesicles from clinical Cutibacterium acnes isolates

ABSTRACT: Recently the membrane vesicles (MVs) production has been observed in Gram-positive bacterium, Cutibacterium acnes (C. acnes). In order to explore the mechanism of antibiotic resistance and the virulent components within the C. acnes-derived MVs, we isolated MVs from the clinical C. acnes, which were sensitive or resistant to antibiotics erythromycin and clindamycin. With the LC-MS/MS method, we detected several lipases, virulent factors and cell division protein differentially expressed between the sensitive and the resistant C. acnes-derived MVs.

INSTRUMENT(S):

ORGANISM(S): Cutibacterium Acnes Sk137

TISSUE(S): Cell Culture

SUBMITTER: Min Jiang  

LAB HEAD: Ying Ma

PROVIDER: PXD025460 | Pride | 2022-05-20

REPOSITORIES: Pride