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Circ101093 regulated proteins in Lung carcinoma (LUAD) cells.

ABSTRACT: Circ101093 was knocked down in A549 LUAD cell lines, and overexpressed in H1975 LUAD cell lines. Then, downregulated proteins in A549 cell lines and upregulated proteins in H1975 cell lines were analyzed.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: zhang xiao

LAB HEAD: Jiayi Wang

PROVIDER: PXD025491 | Pride | 2022-05-20

REPOSITORIES: Pride

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Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma.

Zhang Xiao X Xu Yunhua Y Ma Lifang L Yu Keke K Niu Yongjie Y Xu Xin X Shi Yi Y Guo Susu S Xue Xiangfei X Wang Yikun Y Qiu Shiyu S Cui Jiangtao J Wang Hong H Tian Xiaoting X Miao Yayou Y Meng Fanyu F Qiao Yongxia Y Yu Yongchun Y Wang Jiayi J

Cancer communications (London, England) 20220220 4

<h4>Background</h4>Resistance to ferroptosis, a regulated cell death caused by iron-dependent excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma (LUAD). Intracellular antioxidant systems are required for protection against ferroptosis. The purpose of the present study was to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.<h4>Methods</h4>Established human lung fibroblasts MRC-5, WI38, and human LUAD H1650, PC9, H1975 ...[more]

PMID: 35184419

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