Proteomics

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Comparative proteomics of paired human vocal fold and oral mucosa tissue

ABSTRACT: This dataset brief is about the descriptive proteomic comparison of human oral mucosa and vocal fold tissues by high-resolution mass spectrometry (CID-MS/MS). The vast majority of voice disorders is associated with changes of the unique but delicate tissue of the human vocal folds, wheras the ability to develop new effective treatment methods is significantly limited by the physical inaccessibility and the extremely rare occasion to gather healthy tissue biopsies. Therefore, oral mucosa reached specific interest for laryngological research, as the tissue harvesting process is less invasive and accompanied with faster healing and less scarring. Proteomic analysis of both tissues will provide a fundamental laryngological resource for the research community. Our study identifies a total of 1575 proteins detected within both tissues that are highly consistent in several crucial biological processes, cellular components, and molecular functions.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oral Epithelium, Vocal Fold, Oral Mucosa

SUBMITTER: Barbara Darnhofer  

LAB HEAD: ruth birner-gruenberger

PROVIDER: PXD025519 | Pride | 2021-12-30

REPOSITORIES: Pride

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Descriptive proteomics of paired human vocal fold and buccal mucosa tissue.

Grossmann Tanja T   Darnhofer Barbara B   Birner-Gruenberger Ruth R   Kirsch Andrijana A   Gugatschka Markus M  

Proteomics. Clinical applications 20211201 2

The vast majority of voice disorders is associated with changes of the unique, but delicate, human vocal fold mucosa. The ability to develop new effective treatment methods is significantly limited by the physical inaccessibility and the extremely rare occasions under which healthy tissue biopsies can be obtained. Therefore, the interest in laryngological research has shifted to human oral (buccal) mucosa, a similar and more easily available tissue. The harvesting process is less invasive and ac  ...[more]

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