Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Christof Lenz
LAB HEAD: Christof Lenz
PROVIDER: PXD025569 | Pride | 2021-12-30
REPOSITORIES: Pride
Güran Alican A Ji Yanlong Y Fang Pan P Pan Kuan-Ting KT Urlaub Henning H Avkiran Metin M Lenz Christof C
International journal of molecular sciences 20211122 22
β-adrenergic receptor (β-AR) stimulation represents a major mechanism of modulating cardiac output. In spite of its fundamental importance, its molecular basis on the level of cell signalling has not been characterised in detail yet. We employed mass spectrometry-based proteome and phosphoproteome analysis using SuperSILAC (spike-in stable isotope labelling by amino acids in cell culture) standardization to generate a comprehensive map of acute phosphoproteome changes in mice upon administration ...[more]