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Huh-7 Over-expression FNDC4 LC-MS

ABSTRACT: To clarify the molecular mechanism by which FNDC4 promotes HCC invasion, mass spectrometry (MS) analysis was performed on the lysates of Huh-7-overexpressing FNDC4 and normal Huh-7 cells.

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte

DISEASE(S): Liver Cancer

SUBMITTER: shuguo zheng

LAB HEAD: Shuguo Zheng

PROVIDER: PXD025623 | Pride | 2022-02-17

REPOSITORIES: Pride

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FNDC4 acts as an extracellular factor to promote the invasiveness of hepatocellular carcinoma partly via the PI3K/Akt signalling pathway.

Wang Baolin B Zheng Bowen B Lu Yao Y Huang Deng D Liu Jialong J Song Juxian J Zheng Shuguo S

Cancer medicine 20210821 20

FNDC4 is highly homologous to the exercise-associated myokine FNDC5/irisin, which is highly expressed and promotes the invasion and metastasis of HCC cells. However, the function of FNDC4 remains unknown. Here, we report that FNDC4, an extracellular factor, plays important roles in the invasion and metastasis of HCC. We found that high FNDC4 expression is associated with poor survival in HCC patients and FNDC4 promotes the migration and invasion of HCC cells. Mechanistically, we found that FNDC4 ...[more]

PMID: 34418326

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