Dietary fiber deficiency promotes cognitive impairment through the gut-hippocampal axis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: 
Xing Ge
LAB HEAD: Yinghua Yu
PROVIDER: PXD025638 | Pride | 2022-02-17
REPOSITORIES: Pride
Publications
A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites.
Shi Hongli H Ge Xing X Ma Xi X Zheng Mingxuan M Cui Xiaoying X Pan Wei W Zheng Peng P Yang Xiaoying X Zhang Peng P Hu Minmin M Hu Tao T Tang Renxian R Zheng Kuiyang K Huang Xu-Feng XF Yu Yinghua Y
Microbiome 20211111 1
<h4>Background</h4>Cognitive impairment, an increasing mental health issue, is a core feature of the aging brain and neurodegenerative diseases. Industrialized nations especially, have experienced a marked decrease in dietary fiber intake, but the potential mechanism linking low fiber intake and cognitive impairment is poorly understood. Emerging research reported that the diversity of gut microbiota in Western populations is significantly reduced. However, it is unknown whether a fiber-deficien ...[more]
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