Human salivary extracellular vesicles LC-MS/MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Saliva
DISEASE(S): Sjogren's Syndrome
SUBMITTER: 
Francesco Finamore
LAB HEAD: Francesco Finamore
PROVIDER: PXD025649 | Pride | 2021-06-10
REPOSITORIES: Pride
Publications
Characterization of Extracellular Vesicle Cargo in Sjögren's Syndrome through a SWATH-MS Proteomics Approach.
Finamore Francesco F Cecchettini Antonella A Ceccherini Elisa E Signore Giovanni G Ferro Francesco F Rocchiccioli Silvia S Baldini Chiara C
International journal of molecular sciences 20210504 9
Primary Sjögren's syndrome (pSS) is a complex heterogeneous disease characterized by a wide spectrum of glandular and extra-glandular manifestations. In this pilot study, a SWATH-MS approach was used to monitor extracellular vesicles-enriched saliva (EVs) sub-proteome in pSS patients, to compare it with whole saliva (WS) proteome, and assess differential expressed proteins between pSS and healthy control EVs samples. Comparison between EVs and WS led to the characterization of compartment-specif ...[more]
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