Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Gustavo Silva
LAB HEAD: Gustavo Silva
PROVIDER: PXD025726 | Pride | 2022-08-12
REPOSITORIES: Pride
Simões Vanessa V Cizubu Blanche K BK Harley Lana L Zhou Ye Y Pajak Joshua J Snyder Nathan A NA Bouvette Jonathan J Borgnia Mario J MJ Arya Gaurav G Bartesaghi Alberto A Silva Gustavo M GM
Cell reports 20220501 8
Protein ubiquitination is an essential process that rapidly regulates protein synthesis, function, and fate in dynamic environments. Within its non-proteolytic functions, we showed that K63-linked polyubiquitinated conjugates heavily accumulate in yeast cells exposed to oxidative stress, stalling ribosomes at elongation. K63-ubiquitinated conjugates accumulate mostly because of redox inhibition of the deubiquitinating enzyme Ubp2; however, the role and regulation of ubiquitin-conjugating enzymes ...[more]