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Proteomic response of rat hippocampus under chronic unpredicted mild stress reveals insights into susceptibility and insensitivity to depression

ABSTRACT: We used a chronic unpredicted mild stress (CUMS) protocol to separate depression-susceptible and stress-insensitive rat subgroups. Differential proteomes in the hippocampus were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Qing Tian

LAB HEAD: Qing Tian

PROVIDER: PXD025773 | Pride | 2022-02-17

REPOSITORIES: Pride

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Emodin Prevented Depression in Chronic Unpredicted Mild Stress-Exposed Rats by Targeting miR-139-5p/5-Lipoxygenase.

Zhang Teng T Yang Can C Chu Jiang J Ning Lin-Na LN Zeng Peng P Wang Xiao-Ming XM Shi Yan Y Qin Bao-Jian BJ Qu Na N Zhang Qi Q Tian Qing Q

Frontiers in cell and developmental biology 20210726

<h4>Background</h4>The use of medicinal plant ingredients is one of the goals of developing potential drugs for treating depression. Compelling evidence suggests that anti-inflammatory medicines may block the occurrence of depression. We studied the effect of a natural compound, emodin, on the development of psychosocial stress-induced depression and the underlying mechanisms.<h4>Methods</h4>Chronic unpredicted mild stress (CUMS) for 7 weeks was performed to replicate psychosocial stress in rats ...[more]

PMID: 34381778

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