Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
SUBMITTER: vittoria matafora
LAB HEAD: Angela Bachi
PROVIDER: PXD025809 | Pride | 2022-02-17
REPOSITORIES: Pride
Fajner Valentina V Giavazzi Fabio F Sala Simona S Oldani Amanda A Martini Emanuele E Napoletano Francesco F Parazzoli Dario D Cesare Giuliana G Cerbino Roberto R Maspero Elena E Vaccari Thomas T Polo Simona S
Nature communications 20210916 1
Specialised ribonucleoprotein (RNP) granules are a hallmark of polarized cells, like neurons and germ cells. Among their main functions is the spatial and temporal modulation of the activity of specific mRNA transcripts that allow specification of primary embryonic axes. While RNPs composition and role are well established, their regulation is poorly defined. Here, we demonstrate that Hecw, a newly identified Drosophila ubiquitin ligase, is a key modulator of RNPs in oogenesis and neurons. Hecw ...[more]