Proteomics

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Bi-directional epithelial-mesenchymal crosstalk provides self-sustaining pro-fibrotic signals in pulmonary fibrosis


ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic lung disease with a median survival of 2-4 years. Injury to and/or dysfunction of alveolar epithelium are strongly implicated in IPF disease initiation, but what factors determine why fibrosis progresses rather than normal tissue repair occurs remain poorly understood. We previously demonstrated that ZEB1-mediated epithelial-mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells augments TGF-β-induced profibrogenic responses in underlying lung fibroblasts by paracrine signalling. Here we investigated bi-directional epithelial-mesenchymal crosstalk and its potential to drive fibrosis progression. RNA sequencing (RNA-seq) of lung fibroblasts exposed to conditioned media from ATII cells undergoing RAS-induced EMT identified many differentially expressed genes including those involved in cell migration and extracellular matrix (ECM) regulation. We confirmed that paracrine signalling between AS-activated ATII cells and fibroblasts augmented fibroblast recruitment and demonstrated that this involved a ZEB1-tissue plasminogen activator (tPA) axis. In a reciprocal fashion, paracrine signalling from TGF-β-activated lung fibroblasts or IPF fibroblasts induced RAS activation in ATII cells, at least partially via the secreted protein, SPARC. Together these data identify that aberrant bi-directional epithelial-mesenchymal crosstalk in IPF drives a chronic feedback loop that maintains a wound-healing phenotype and provides self-sustaining pro-fibrotic signals.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Caenorhabditis elegans   Lineus longissimus   Mycobacterium tuberculosis H37Rv   Cercopithecidae   unclassified Candidatus Omnitrophica   Malus domestica   Mycobacteroides abscessus   Lysiphlebus fabarum   Mollivirus sibericum   Rhodococcus jostii RHA1   Chlamydomonas reinhardtii   Cicer arietinum   Nelumbo nucifera   Physcomitrium patens   Sphingomonas sp. Leaf257   Theobroma cacao   Spiroplasma melliferum KC3   Pyricularia oryzae   Tuber albidum   Mucilaginibacter   Schizophyllum commune H4-8   Echinococcus granulosus   Sophora alopecuroides   Enterococcus faecalis   Exiguobacterium sp. SH31   Strigomonas culicis   Liquorilactobacillus hordei   Dentex dentex   Onchocerca volvulus   Xenopus laevis   Strongylocentrotus purpuratus   Ruminiclostridium papyrosolvens DSM 2782   Haptophyta   Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150   Mytilus edulis   Mycobacterium marinum ATCC BAA-535   Eremothecium gossypii   Arabidopsis   unidentified   Lingula anatina   gut metagenome   Aspergillus aff. niger A2   Toxoplasma gondii   Lotus japonicus   Selaginella moellendorffii   Pseudomonas aeruginosa PAO1   Quercus ilex   Lactococcus lactis subsp. lactis Il1403   Fusarium oxysporum f. sp. cucumerinum   Streptococcus pneumoniae TIGR4   Olavius algarvensis Gamma 3 endosymbiont   Cervus nippon nippon   Olavius algarvensis sulfate-reducing endosymbiont   Aspergillus terreus NIH2624   Mus musculus   Pseudotsuga menziesii   Macaca fascicularis   Naja sagittifera   Clostridium phage c-st   Burkholderia sp. 2332   Trypanosoma brucei brucei   Saccharum hybrid cultivar   Ciona intestinalis   Staphylococcus sp. 1   Salmonella enterica subsp. enterica serovar Typhimurium str. SDT1291   Piaractus mesopotamicus   Thermochaetoides thermophila   H1N1 subtype   Mycobacterium tuberculosis SP7   Sorghum bicolor   Vibrio parahaemolyticus   Fusarium graminearum GZ3639   Oryzias latipes   Synechocystis sp. PCC 6803   Naja ashei   Campylobacter concisus UNSWCD   Physcomitrella   Oenococcus oeni   Roseburia   Trypanosoma cruzi strain Esmeraldo   Thermoplasma acidophilum DSM 1728   Avena strigosa   Oryza sativa   Anopheles culicifacies A   Dokdonia sp. MED134   Bacillus cereus ATCC 10987   Aspergillus nidulans   Granulicella sp.   Nephila clavipes   Pteropus alecto   Zygaena filipendulae   Chromatiales bacterium OalgGamma1   Paucilactobacillus suebicus   Sorangium cellulosum So ce56   Delonix regia   Synechococcus phage syn9   Armoracia rusticana   Deinococcus radiodurans R1   Helianthus annuus   Halobacterium   Emiliania huxleyi   Tequatrovirus T4   Aedes aegypti densovirus   Glia   Cyprinus carpio   Clostridioides difficile R20291   Brassica oleracea var. italica   Francisella tularensis subsp. holarctica   Sus scrofa domesticus   Oryctolagus sp. 'Rabbit_OD'   Streptococcus pneumoniae D39   Taenia hydatigena   Pseudomonas aeruginosa PAO1H2O   Glycine max   Meleagris gallopavo   Bacteria   Pan troglodytes   Streptococcus thermophilus LMD-9   Sinorhizobium meliloti BL225C   Spirochaeta sp. ELBA   Siphoviridae   Helicobacter pylori J99   Ustilaginoidea virens   Mycoplasma gallisepticum S6   Synechococcus cyanophage syn   Kluyveromyces marxianus   Tarenaya hassleriana   Burkholderia ubonensis MSMB22   Streptococcus agalactiae FSL S3-026   Rhizobium sp. Leaf68   Leishmania donovani   Sanghuangporus   Apis mellifera   Lactobacillus johnsonii N6.2   Faustovirus   Dirofilaria immitis   Desulfovibrio ferrophilus   Andreprevotia sp. IGB-42   Mytilus edulis/galloprovincialis MCLGV-2007   Alternaria tomato   Klebsiella pneumoniae   Populus yunnanensis   Lactococcus lactis subsp. cremoris UC509.9   Bovine leukemia virus   Saccharina japonica   Daphnia pulex   Paramecium tetraurelia   Trypanosoma cruzi strain CL Brener   Schizosaccharomyces pombe OY26   Trichoderma reesei RUT C-30   Pyricularia oryzae B157   Bursaphelenchus xylophilus   Paenibacillus sp.   Brachypodium distachyon   Bothrops jararacussu   Homo sapiens   Pisum sativum   Breviolum minutum   Sedum plumbizincicola   Bubalus bubalis   Ophrys x arachnitiformis subsp. archipelagi   Paramoeba perurans   Bombus terrestris audax   Dictyostelium discoideum AX4   Rhizophagus irregularis   Fagus grandifolia   Acanthamoeba castellanii   Durusdinium trenchii   sediment metagenome   Ianthella basta   Quercus suber   Trypanosoma   Picea abies   Schizosaccharomyces pombe 927   Fraxinus nigra   Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S   Giardia lamblia ATCC 50803   Solanum lycopersicum   Entamoeba histolytica   Dasypogon diadema   Phytophthora capsici LT1534   Candidatus Pelagibacter ubique   Francisella tularensis   Fasciola hepatica   Synechococcus elongatus   Cladocopium goreaui   Mycobacterium tuberculosis SP1   Vipera berus berus   Viridiplantae   Crithidia fasciculata   Hyalella azteca   Scophthalmus maximus   Geobacter sulfurreducens   Vicia faba   Stenotrophomonas maltophilia   Clostridium tetani E88   Cryptococcus neoformans var. grubii H99W   Herpes simplex virus unknown type   Clostridioides difficile 050-P50-2011   Capsicum annuum   Pseudomonas putida KT2440   Euzebya tangerina   Bothrops cotiara   Nicotiana benthamiana   Myxococcus xanthus DK 1622   freshwater sediment metagenome   Dactylorhiza   Microcystis aeruginosa   Tuber aestivum   Brachyspiraceae   Bungarus   prokaryotic environmental samples   Chlamydia trachomatis 434/Bu   Dioscorea alata   Cavia porcellus   Severe acute respiratory syndrome coronavirus 2   Aggregatibacter actinomycetemcomitans   Trichoderma reesei QM6a   Callinectes sapidus   Malassezia sympodialis ATCC 42132   mixed culture metagenome   Sarcophilus harrisii   Bienertia sinuspersici   Chlorocebus sabaeus   Potentilla saundersiana   Saccostrea glomerata   Schizosaccharomyces pombe   Oreochromis niloticus niloticus   Dendroaspis angusticeps   Human herpesvirus 2 strain 186   Citrullus lanatus   Epstein-barr virus strain p3hr-1   Citrus maxima   Zea mays   Listeria monocytogenes EGD-e   Leishmania donovani Ld 2001   Human alphaherpesvirus 1 strain 17   Nematostella vectensis   Danio rerio   Mus musculus musculus x Mus musculus castaneus   Candidatus Kuenenia stuttgartiensis   Archaea   uncultured marine microorganism   Ficus carica   Ophrys garganica   Oryctolagus cuniculus algirus   Natronomonas pharaonis DSM 2160   Oreochromis mossambicus   Cyclopes didactylus   Riptortus pedestris   Yersinia pestis   Naja naja   Peniophora incarnata   Botrytis cinerea B05.10   Capsicum annuum var. annuum   Allexis   Flavobacterium columnare   Perkinsus marinus   Globicatella sanguinis   Campylobacter fetus subsp. fetus 82-40   Crotalus durissus terrificus   Mycobacterium tuberculosis SP10   Medicago truncatula var. truncatula   Cleome angustifolia   Trichechus manatus   Brucella abortus S19   Thermococcus gammatolerans EJ3   Coronavirus PREDICT CoV-2   Gynandropsis gynandra   Scutigera coleoptrata   Burkholderia cenocepacia K56-2Valvano   Escherichia coli   Drosophila melanogaster   Ursus arctos arctos   Faecalibacterium prausnitzii   Arvicola   Beauveria bassiana ARSEF 2860   Ceratopteris richardii   Campylobacter jejuni   Strigamia maritima   Pseudomonas fluorescens SBW25   Candida albicans   Lithobius forficatus   Streptococcus pyogenes M1 GAS   Neptuniibacter caesariensis   Listeria monocytogenes   Strawberry leafy fruit phytoplasma   Drosophila   Norovirus   Francisella tularensis subsp. holarctica LVS   Orycteropus afer   Volvariella volvacea V23   Cecropia peltata   Streptococcus pyogenes STAB901   Vitis vinifera   Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10   Olavius algarvensis   Haloferax volcanii DS2   Thermochaetoides thermophila DSM 1495   Burkholderia cenocepacia   Rattus norvegicus   Plasmodium knowlesi strain H   Botrytis cinerea   Ensifer adhaerens   Quercus petraea   Roseobacter sp. MED193   Streptococcus pneumoniae SP14-BS69   Deinococcus deserti VCD115   Morchella importuna   Rhizobium cf. leguminosarum   Giardia intestinalis assemblage A   Aspergillus flavus NRRL3357   Acidithiobacillus ferrooxidans ATCC 53993   Lagomorpha   Pyrus x bretschneideri   Bradyrhizobium   Mycobacterium avium subsp. paratuberculosis K-10   Megoura viciae   Parasynechococcus marenigrum WH 8102   Clostridioides difficile ATCC 43255   Sciuridae   Saccharomyces cerevisiae W303   Camelus dromedarius   Bothrops neuwiedi   Pogona vitticeps   Hordeum vulgare   [Candida] glabrata   Pogonomyrmex rugosus   Bodo saltans   Ustilago maydis   Shewanella baltica   Mycolicibacterium smegmatis MC2 155   Drosophila pseudoobscura   Coffea canephora   Naja mandalayensis   Haemophilus influenzae   Catalpa fargesii   Phascolarctos cinereus   Lacticaseibacillus rhamnosus GG   Toxoplasma gondii ME49   Brugia malayi   Hydra vulgaris   Enterococcus mundtii CRL35   metagenomes   Arabidopsis thaliana   Euprymna scolopes   Coprococcus eutactus   Sphingobium chlorophenolicum   Zymomonas mobilis   Bombyx mori   Fragaria x ananassa   Acinetobacter baumannii D1279779   Mycobacterium tuberculosis SP22   Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344   Clostridioides difficile 630   Pseudomonas putida BIRD-1   Acipenser transmontanus   Plasmodium sp. pBT9   Corynebacterium glutamicum ATCC 13032   Trypanosoma cruzi   Citrus sinensis   Crassostrea hongkongensis   Mustela putorius furo   Homo sapiens subsp. 'Denisova'   Olavius algarvensis spirochete endosymbiont   Streptomyces coelicolor   Schizosaccharomyces pombe 972h-   Heloderma suspectum suspectum   Hebomoia glaucippe   Trifolium pratense subsp. pratense   Heterorhabditis megidis   Clostridium butyricum E4 str. BoNT E BL5262   Spiroplasma melliferum   Candida albicans SC5314   Human alphaherpesvirus 1   Amaranthus tricolor   Formosa sp. Hel3_A1_48   Coffea eugenioides   Latilactobacillus curvatus   Bicyclus anynana   Bacillus mycoides NBRC 101238 = DSM 11821   Anopheles stephensi   Arachis hypogaea   Mycobacterium tuberculosis   Xanthomonas oryzae pv. oryzae PXO99A   Spondylus gaederopus   Helicobacter pylori 26695   Aspergillus niger   Tapirus terrestris   Russula atropurpurea   Brassica oleracea var. botrytis   Tradescantia spathacea   Brassica oleracea var. gemmifera   Lactococcus phage   Novosphingobium nitrogenifigens   Roseburia intestinalis L1-82   Pseudomonas aeruginosa   Trichoderma reesei QM9414   Agaricus bisporus   Chlamydia trachomatis D/UW-3/CX   Mayaro virus (strain Brazil)   Coxiella burnetii RSA 493   Ictidomys tridecemlineatus   Taeniopygia guttata   Spirometra erinaceieuropaei   Clostridium saccharoperbutylacetonicum   Enchytraeus crypticus   Bothrops leucurus   Olavius algarvensis Delta 1 endosymbiont   Pseudomonas aeruginosa PA14   Mytilus galloprovincialis   Elaeis guineensis   Candidatus Nitrospira inopinata   Panicum virgatum   Borreliella burgdorferi B31   Human herpesvirus 5 strain AD169   Pedobacter sp.   Pseudomonas syringae   Halobacterium salinarum R1   Staphylococcus aureus subsp. aureus USA300_FPR3757   Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499   Pyricularia oryzae P131   Planococcus halocryophilus Or1   Mariprofundus ferrooxydans   Cyanophora paradoxa   Staphylococcus haemolyticus   Cricetulus griseus   Pectobacterium carotovorum   hybrid   Mycoplasma pneumoniae M129-B7   Leishmania major strain Friedlin   Pseudomonas stutzeri   Trichoderma sp. 1 YW-2011   Alteromonadales   Neurospora crassa   Saccharum sp.   Aspergillus niger NRRL3   Vitis   Chlorella vulgaris   Gadus morhua   Candidatus Methylomirabilis oxyfera   Piscirickettsia salmonis AUSTRAL-005   Shigella dysenteriae   Labeo rohita   Hippopotamus amphibius   Escherichia coli O157:H7 str. TW14359   Streptococcus pyogenes ABC020006030   Angiostrongylus cantonensis   Conus geographus   Gossypium hirsutum   Capsaspora owczarzaki   Dictyostelium discoideum   environmental samples   Streptococcus pyogenes   Human alphaherpesvirus 1 strain KOS   Cervus elaphus elaphus   Apis mellifera ligustica   Lactobacillus   Enterobacter cloacae   Neisseria meningitidis MC58   Acanthoscurria geniculata   Candidatus Endoriftia persephone   Tuber magnatum   Escherichia coli O157:H7 str. EDL933   Capra hircus   Phaseolus vulgaris   Gammarus fossarum   Pachysolen tannophilus NRRL Y-2460   Giardia intestinalis   Penaeus vannamei   Octopodiformes   Deltaproteobacteria bacterium RIFCSPLOWO2_12_FULL_50_11   Saccharomyces cerevisiae   Influenza A virus (H1N1)   Gorilla gorilla   Ricinus communis   Channa striata   Phytophthora pisi   environmental samples   Eulimnogammarus cyaneus   Pyrococcus furiosus   Anopheles culicifacies B   Campylobacter concisus 13826   Lens culinaris   Shewanella oneidensis MR-1   Apis mellifera pomonella   Triticum aestivum   Rheum palmatum   Aedes aegypti aegypti   Vibrio anguillarum   Bemisia tabaci   Rhodopseudomonas palustris   Bradyrhizobium diazoefficiens   Desulfovibrio sp. G11   Ophrys sphegodes   Citrobacter rodentium   Dioscorea oppositifolia   Ganoderma lingzhi   Vibrio alginolyticus   Mytilus sp. CHGF4   Bartonella quintana JK 31   Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759   Bacillus subtilis   Francisella orientalis FNO12   unclassified Marseilleviridae   Beta vulgaris subsp. vulgaris   Cytomegalovirus   Plasmodium falciparum 3D7   Actinomycetia   Colinus virginianus   Quercus robur   Candida tropicalis   Schizosaccharomyces pombe DM3650   Shigella sonnei 53G   Bos taurus   Rattus rattus   Cryptochiton stelleri   Streptococcus pneumoniae R6   albimanus section   Paracoccus denitrificans PD1222   Eukaryota   Streptococcus equi subsp. equi 4047   Manica rubida   Bradyrhizobium diazoefficiens USDA 110   Bacillus subtilis subsp. subtilis str. 168   Clostridium autoethanogenum   Listeria phage A118   Mengo virus   Oncorhynchus tshawytscha   biofilm metagenome   [Ruminococcus] gnavus   Legionella pneumophila subsp. pneumophila str. Philadelphia 1   rat gut metagenome   Mylodon darwinii   Tropilaelaps mercedesae   Eubacterium limosum   Mycobacterium tuberculosis M24   environmental samples   Shigella flexneri 2a str. 2457T   Gammarus pulex   Priestia megaterium DSM 319   Daphnia magna   Oryza sativa Indica Group   Asterias rubens   Escherichia coli O157:NM   Austrolebias   Staphylococcus aureus subsp. aureus NCTC 8325   Escherichia coli O157:H7   Dinoroseobacter shibae DFL 12 = DSM 16493   Struthio camelus   Phytophthora capsici   Human immunodeficiency virus   Mycoplasmopsis agalactiae   Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841   Oryza sativa Japonica Group   Bothrops jararaca   Streptococcus agalactiae   Coxiella burnetii   Blumeria hordei DH14   Viruses   Oryctolagus cuniculus   Muvirus mu   Vitis riparia   Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821   Granulicatella adiacens ATCC 49175   Cryptococcus neoformans var. grubii H99   Betaproteobacteria bacterium RIFCSPLOWO2_02_64_14   Thermus thermophilus HB8   Candidatus Thioglobus autotrophicus   Entamoeba histolytica HM-1:IMSS-A   Fraxinus mandshurica   Salmo salar   Lachancea kluyveri   Mycolicibacterium smegmatis   Toxoplasma gondii type III   Gammarus roeselii   Pongo pygmaeus   Bothrops moojeni   Bacillus mycoides DSM 2048   Hepatitis E virus type 1   Synechocystis sp. PCC 6803 substr. Kazusa   Cupiennius salei   Thermothelomyces thermophilus ATCC 42464   Olavius algarvensis Delta 4 endosymbiont   Synechocystis sp. PCC 6803 substr. GT-I   rhizosphere soil bacteria ensemble   Latrodectus hesperus   Boehmeria nivea   Photobacterium profundum SS9   Phytophthora sojae   Acinetobacter baumannii AB307-0294   Desulforamulus reducens MI-1   Staphylococcus aureus   Puccinellia tenuiflora   Ictalurid herpesvirus 1   environmental samples   Bacteroides caccae   Salmo sp.   Methylocystis sp. SC2   Brucella melitensis   Thalassiosira pseudonana CCMP1335   Equus asinus   Daktulosphaira vitifoliae   Craterostigmus tasmanianus   Halobacterium salinarum   Dialister   Aspergillus flavus   Paracoccidioides brasiliensis Pb18   Coxsackievirus B3   Bartonella quintana   Leishmania braziliensis MHOM/BR/75/M2904   Solanum tuberosum   Tuber melanosporum Mel28   Porphyromonas gingivalis W83   Scheffersomyces stipitis   Pseudotsuga menziesii var. menziesii   Murine leukemia virus   Bacillus thuringiensis serovar berliner ATCC 10792   Acinetobacter baumannii ACICU   Plasmodium berghei ANKA   Larimichthys crocea   environmental samples   Steinernema carpocapsae   uncultured Phormidium sp.   Mycoplasma pneumoniae M129   Myzus persicae   Candidatus Accumulibacter   Burkholderia pseudomallei 1026b   Sarcoptes scabiei   Passiflora edulis   Brucella abortus   Trichomonas gallinae   Equus caballus   Populus trichocarpa   Canis lupus familiaris   Acyrthosiphon pisum   Rhipicephalus microplus   Melioribacter roseus P3M-2   Populus tremula x Populus alba   Neisseria gonorrhoeae FA 1090   Pseudomonas putida F1   Butyrivibrio fibrisolvens   Olavius algarvensis Gamma 1 endosymbiont   Marchantia polymorpha subsp. ruderalis   Leishmania mexicana   Crassostrea gigas   Trypanosoma brucei   Parhyale hawaiensis   Tuber indicum   Cyclotella cryptica   Anas platyrhynchos   Streptomyces coelicolor A3(2)   Candidatus Accumulibacter phosphatis   Flavobacterium sp. 316   Vibrio cholerae O1 biovar El Tor str. N16961   Syntrophomonas wolfei   Canis lupus x Canis lupus familiaris   Mycobacterium tuberculosis SP13   Corynebacterium diphtheriae NCTC 13129   Ruminiclostridium cellulolyticum H10   Oryctolagus cuniculus cuniculus   Medicago truncatula   Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044   Schistosoma haematobium   Podospora anserina S mat+   Simulium damnosum s.l. Me1   Eriocheir sinensis   Hendra virus horse/Australia/Hendra/1994   Piper nigrum   Francisella tularensis subsp. holarctica FSC200   Plasmodium falciparum   Noccaea caerulescens   anaerobic digester metagenome   Saccharomyces cerevisiae EC1118   Medicago sativa   human metagenome   Brassica napus   Apostichopus japonicus   Komagataella pastoris   Dendroaspis polylepis polylepis   Aspergillus fumigatus Af293   Calicophoron daubneyi   Chlorocebus aethiops   Homo   Lactococcus lactis subsp. cremoris MG1363   Felis catus   Trypanosoma brucei brucei TREU927   Renibacterium salmoninarum ATCC 33209   Human immunodeficiency virus 1   Acanthoscurria gomesiana   Phytophthora infestans   Aerococcus urinae NBRC 15544 = CCUG 36881   Mesocricetus auratus   Salmonella enterica subsp. enterica serovar Enteritidis str. P125109   Thalassiosira cf. oceanica   Scolopendra morsitans   Oncorhynchus mykiss   Luteibacter   Liquorilactobacillus nagelii   Sus scrofa   Riftia pachyptila   Leishmania major   Plasmodium yoelii yoelii   Taenia solium   Clavibacter michiganensis subsp. nebraskensis NCPPB 2581   Tetrahymena thermophila   Salmonella enterica subsp. enterica serovar Typhi str. CT18   Yersinia enterocolitica   Chlorella sp. SAG 211-18   Pinus radiata   Gallus gallus   Schistosoma mansoni   Teleogryllus oceanicus   Mycobacterium tuberculosis KZN 1435   (Vitis vinifera x Vitis berlandieri) x Vitis berlandieri   Bacillus pseudomycoides DSM 12442   Chenopodium quinoa   Ostreococcus tauri   Apteronotus leptorhynchus   Palaemonetes sp. common grass shrimp associated circular virus   Nicotiana tabacum   Bacillus amyloliquefaciens   Coffea arabica   Ovis aries   Emiliania   Heterosigma akashiwo   Saccharopolyspora erythraea   Clostridium perfringens   Synechococcus elongatus PCC 7942 = FACHB-805   Bradyrhizobium japonicum   Ctenopharyngodon idella   Amphibalanus amphitrite   Aves   Cloning vector pEGFP-C1   Pyrococcus abyssi   Cupriavidus metallidurans   Heliocidaris erythrogramma   Leishmania infantum JPCM5   Bothrops brazili   Catenibacterium   Escherichia coli BL21(DE3)   Ascaris suum   Picea likiangensis var. rubescens   Trichinella britovi   Bacillus cereus ATCC 14579   Bordetella pertussis Tohama I   Streptococcus dysgalactiae subsp. equisimilis SK1249   Macaca mulatta   Pseudomonas pseudoalcaligenes CECT 5344   Bothrops insularis   Acinetobacter baumannii   Escherichia coli K-12   soil bacterium TS1114R   Histomonas meleagridis   Bacillus toyonensis BCT-7112   Bacillus cytotoxicus NVH 391-98   Synechococcus phage S-SSM7   Brucella   Moraxella catarrhalis   Phaeobacter sp. MED193   Trichoderma harzianum CBS 226.95   Aspergillus nidulans TN02A3   Lentinus crinitus   Streptomyces avidinii  

TISSUE(S): Fibroblast

SUBMITTER: Paul Skipp  

LAB HEAD: Paul James Skipp

PROVIDER: PXD025821 | Pride | 2021-08-19

REPOSITORIES: Pride

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