Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): T Cell, Small Intestine
DISEASE(S): Celiac Disease
SUBMITTER: Renata Soares
LAB HEAD: Mahima Swamy
PROVIDER: PXD025891 | Pride | 2021-05-10
REPOSITORIES: Pride
Nature communications 20210713 1
Intestinal intraepithelial lymphocytes (IEL) are an abundant population of tissue-resident T cells that protect and maintain the intestinal barrier. IEL respond to epithelial cell-derived IL-15, which is complexed to the IL-15 receptor α chain (IL-15/Rα). IL-15 is essential both for maintaining IEL homeostasis and inducing IEL responses to epithelial stress, which has been associated with Coeliac disease. Here, we apply quantitative mass spectrometry to IL-15/Rα-stimulated IEL to investigate how ...[more]