Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Human Coronavirus Hku1 (isolate N1)
TISSUE(S): T Cell, Cell Culture
DISEASE(S): Severe Acute Respiratory Syndrome
SUBMITTER: Dongmei Fu
LAB HEAD: Dongmei Fu
PROVIDER: PXD025967 | Pride | 2022-02-17
REPOSITORIES: Pride
Frontiers in chemistry 20210813
HKU1 is a human beta coronavirus and infects host cells <i>via</i> highly glycosylated spike protein (S). The N-glycosylation of HKU1 S has been reported. However, little is known about its O-glycosylation, which hinders the in-depth understanding of its biological functions. Herein, a comprehensive study of O-glycosylation of HKU1 S was carried out based on dual-functional histidine-bonded silica (HBS) materials. The enrichment method for O-glycopeptides with HBS was developed and validated usi ...[more]