Acetylome Profiling Reveals the Endogenous Substrates of HDAC6

ABSTRACT: HDAC6 inhibitors are novel targeted therapies showing good clinical response in a variety of different malignancies. However, their use and farther development is hampered by the limited knowledge regarding what are the endogenous substrates of HDAC6 enzyme. Here we plan to complete acetylome profiling of HAP1 cells with and without HDAC6 knockout to identify which are the HDAC6 substrates and what are the differences between the wildtype and HDAC6-KO cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yuxin Li  

LAB HEAD: Junmin Peng

PROVIDER: PXD026010 | Pride | 2022-11-09

REPOSITORIES: Pride