Proteomics

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TMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposureTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposure

ABSTRACT: The proteome cargo of extracellular vesicles released from brown adipose tissue (BAT) and from white adipose tissue (WAT) of mice subjected to cold exposure (4°C) was analysed by a TMT-based quantitative proteomic procedure in order to obtain new information on the processes of thermogenesis.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brown Adipose Tissue, White Adipose Tissue

SUBMITTER: Giovanni Renzone  

LAB HEAD: Andrea Scaloni

PROVIDER: PXD026080 | Pride | 2022-05-20

REPOSITORIES: Pride

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Publications

Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.

Rosina Marco M   Ceci Veronica V   Turchi Riccardo R   Chuan Li L   Borcherding Nicholas N   Sciarretta Francesca F   Sánchez-Díaz María M   Tortolici Flavia F   Karlinsey Keaton K   Chiurchiù Valerio V   Fuoco Claudia C   Giwa Rocky R   Field Rachael L RL   Audano Matteo M   Arena Simona S   Palma Alessandro A   Riccio Federica F   Shamsi Farnaz F   Renzone Giovanni G   Verri Martina M   Crescenzi Anna A   Rizza Salvatore S   Faienza Fiorella F   Filomeni Giuseppe G   Kooijman Sander S   Rufini Stefano S   de Vries Antoine A F AAF   Scaloni Andrea A   Mitro Nico N   Tseng Yu-Hua YH   Hidalgo Andrés A   Zhou Beiyan B   Brestoff Jonathan R JR   Aquilano Katia K   Lettieri-Barbato Daniele D  

Cell metabolism 20220318 4

Recent findings have demonstrated that mitochondria can be transferred between cells to control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a large component of the cell volume and undergo reorganization to sustain thermogenesis, it remains unclear whether an intercellular mitochondrial transfer occurs in brown adipose tissue (BAT) and regulates adaptive thermogenesis. Herein, we demonstrated that thermogenically stressed brown adipocytes release extracellular v  ...[more]

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