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COVID-19 patient plasma exosome proteomics

ABSTRACT: Proteomics analysis of exosomes isolated from four temporal phases of COVID-19

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Ni zhen

LAB HEAD: Guanghou Shui

PROVIDER: PXD026091 | Pride | 2021-05-19

REPOSITORIES: Pride

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A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19.

Lam Sin Man SM Zhang Chao C Wang Zehua Z Ni Zhen Z Zhang Shaohua S Yang Siyuan S Huang Xiahe X Mo Lesong L Li Jie J Lee Bernett B Mei Mei M Huang Lei L Shi Ming M Xu Zhe Z Meng Fan-Ping FP Cao Wen-Jing WJ Zhou Ming-Ju MJ Shi Lei L Chua Gek Huey GH Li Bowen B Cao Jiabao J Wang Jun J Bao Shilai S Wang Yingchun Y Song Jin-Wen JW Zhang Fujie F Wang Fu-Sheng FS Shui Guanghou G

Nature metabolism 20210622 7

Exosomes represent a subtype of extracellular vesicle that is released through retrograde transport and fusion of multivesicular bodies with the plasma membrane<sup>1</sup>. Although no perfect methodologies currently exist for the high-throughput, unbiased isolation of pure plasma exosomes<sup>2,3</sup>, investigation of exosome-enriched plasma fractions of extracellular vesicles can confer a glimpse into the endocytic pathway on a systems level. Here we conduct high-coverage lipidomics with an ...[more]

PMID: 34158670

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