Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Blood
DISEASE(S): Disease Free
SUBMITTER: Michael Hollas
LAB HEAD: Neil L. Kelleher
PROVIDER: PXD026149 | Pride | 2022-02-03
REPOSITORIES: Pride
Items per page: 1 - 5 of 73 |
Science (New York, N.Y.) 20220127 6579
Human biology is tightly linked to proteins, yet most measurements do not precisely determine alternatively spliced sequences or posttranslational modifications. Here, we present the primary structures of ~30,000 unique proteoforms, nearly 10 times more than in previous studies, expressed from 1690 human genes across 21 cell types and plasma from human blood and bone marrow. The results, compiled in the Blood Proteoform Atlas (BPA), indicate that proteoforms better describe protein-level biology ...[more]