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Conus striatus Venom Duct LC/MS/MS

ABSTRACT: The venom of cone snails is highly variable both between and within species, as well as spatially along the venom duct. However, defferences of defensive and predatory venoms in "hook-and-line" fish hunting clades and their venom duct origins has not been investigated. In this study a combination of proteomics and transcriptomic approaches were used to decode the venom profiles of C. striatus from the Pionoconus clade. The raw data files obtained from the reduced alkylated and digested venom duct sections (distal, central and proximal), injected predatory and defensive induced venoms are submitted here.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Conus Striatus

TISSUE(S): Venom Duct

SUBMITTER: Himaya Siddhihalu Hewage

LAB HEAD: Richard Lewis

PROVIDER: PXD026194 | Pride | 2022-02-17

REPOSITORIES: Pride

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Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus.

Himaya S W A SWA Jin Ai-Hua AH Hamilton Brett B Rai Subash K SK Alewood Paul P Lewis Richard J RJ

Scientific reports 20210624 1

The venom duct origins of predatory and defensive venoms has not been studied for hook-and-line fish hunting cone snails despite the pharmacological importance of their venoms. To better understand the biochemistry and evolution of injected predatory and defensive venoms, we compared distal, central and proximal venom duct sections across three specimens of C. striatus (Pionoconus) using proteomic and transcriptomic approaches. A total of 370 conotoxin precursors were identified from the whole v ...[more]

PMID: 34168165

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